CKDdb-logoCKDdb - Molecule ID A8663

geneAPOH, B2G1
nameBeta-2-glycoprotein 1 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOH_HUMANP02749ENSG00000091583350Hs.445358138700

Functions and classifications

GOC:cell surface, C:chylomicron, C:high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:heparin binding, F:lipoprotein lipase activator activity, F:phospholipid binding, P:blood coagulation, intrinsic pathway, P:negative regulation of angiogenesis, P:negative regulation of blood coagulation, P:negative regulation of endothelial cell migration, P:negative regulation of endothelial cell proliferation, P:negative regulation of fibrinolysis, P:negative regulation of myeloid cell apoptotic process, P:negative regulation of smooth muscle cell apoptotic process, P:plasminogen activation, P:positive regulation of lipoprotein lipase activity, P:triglyceride metabolic process, P:triglyceride transport, C:extracellular space, P:regulation of blood coagulation, F:eukaryotic cell surface binding, P:organ regeneration, F:lipid binding, P:blood coagulation
UniProt3D-structure, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Heparin-binding, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Sushi
PADBunknown

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16083269Rattus norvegicus10bloodserumTransplantation (Acute Renal Allograft Rejection)up< 0.05SELDI-MS (CM10, Q10), MALDI-MS/MS16083269
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)22.710.05RNA microarray17579666
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0.14 LC-MS/MS18440303
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0.57 LC-MS/MS18440303
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.00548RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.510.000226863RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.03< 0.05RNA microarray21752957
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)1.370hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23464927Homo sapiens10urine Fabry (12 months of ERT)0.98<0.05QTOF MS/MS23464927
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.45< 0.05RNA-seq23757392
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)1.41< 0.05LC-MS/MS24497609
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)  LC-MS/MS24726496
Exp25666440Homo sapiens23urinesupernatantFabry (naive Fabry patients)4.310.029697nanoLC-ESI-MS/MS25666440

Compile date 08-10-2018© iMODE-CKD consortium