CKDdb-logoCKDdb - Molecule ID A8653

geneAls2
nameAlsin
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALS2_MOUSEQ920R0ENSMUSG0000002602474018Mm.272078205100, 606352, 606353, 607225

Functions and classifications

GOC:centrosome, C:cytosol, C:dendrite, C:dendritic spine, C:early endosome, C:growth cone, C:lamellipodium, C:postsynaptic density, C:protein complex, C:ruffle, C:vesicle, F:protein serine/threonine kinase activator activity, F:Rab GTPase binding, F:Rab guanyl-nucleotide exchange factor activity, F:Rac guanyl-nucleotide exchange factor activity, F:Ran guanyl-nucleotide exchange factor activity, P:behavioral fear response, P:cell death, P:endosomal transport, P:endosome organization, P:locomotory behavior, P:neuromuscular junction development, P:neuron projection morphogenesis, P:positive regulation of Rac GTPase activity, P:positive regulation of Rac protein signal transduction, P:protein localization, P:receptor recycling, P:regulation of endosome size, P:response to oxidative stress, P:synaptic transmission, glutamatergic, P:vesicle organization, F:Rho guanyl-nucleotide exchange factor activity, P:regulation of Rho GTPase activity, C:cytoplasm, P:regulation of Rab GTPase activity, "C:axon, C:centrosome, C:membrane, C:neuronal cell body, F:phospholipid binding, P:axonogenesis, P:in utero embryonic development, P:Rac protein signal transduction, C:intracellular, P:regulation of Rho protein signal transduction
UniProtAcetylation, Alternative splicing, Amyotrophic lateral sclerosis, Complete proteome, Guanine-nucleotide releasing factor, Neurodegeneration, Phosphoprotein, Polymorphism, Reference proteome, Repeat
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.160.019889449LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.498.21E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium