CKDdb-logoCKDdb - Molecule ID A8651

geneAIMP1, EMAP2, SCYE1
nameMultisynthetase complex auxiliary component p43
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AIMP1_HUMANQ12904ENSG000001640229255Hs.591680260600, 603605

Functions and classifications

GOC:aminoacyl-tRNA synthetase multienzyme complex, C:cell surface, C:cytosol, C:endoplasmic reticulum, C:extracellular space, C:Golgi apparatus, C:nucleus, C:transport vesicle, F:cytokine activity, F:protein homodimerization activity, F:tRNA binding, P:angiogenesis, P:apoptotic process, P:cell adhesion, P:cell-cell signaling, P:chemotaxis, P:glucose metabolic process, P:inflammatory response, P:leukocyte migration, P:negative regulation of endothelial cell proliferation, P:signal transduction, P:tRNA aminoacylation for protein translation, F:cell surface binding
UniProt3D-structure, Acetylation, Alternative splicing, Angiogenesis, Apoptosis, Carbohydrate metabolism, Cell adhesion, Complete proteome, Cytokine, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Glucose metabolism, Golgi apparatus, Inflammatory response, Leukodystrophy, Nucleus, Polymorphism, Protein biosynthesis, Reference proteome, RNA-binding, Secreted, tRNA-binding
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.88.15E-09RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)4.470.000105RNA microarray19698090
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)2.65< 0.05LC-MS/MS19845401
Exp24172336Mus musculus6kidneycortexAKI (AKI)2.150.007925585LC-MS/MS24172336
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)0.480.049677205LC-MS/MS24316357
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.441.78E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium