CKDdb-logoCKDdb - Molecule ID A8416

geneCAST
nameCalpain inhibitor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ICAL_HUMANP20810ENSG00000153113831Hs.436186114090

Functions and classifications

GOC:membrane, F:cysteine-type endopeptidase inhibitor activity, F:endopeptidase inhibitor activity, P:negative regulation of type B pancreatic cell apoptotic process, F:calcium-dependent cysteine-type endopeptidase inhibitor activity, P:negative regulation of peptidase activity
UniProtAlternative splicing, Complete proteome, Phosphoprotein, Polymorphism, Protease inhibitor, Reference proteome, Repeat, Thiol protease inhibitor
PADBinhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.380.000000816RNA microarray19698090
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)1.41< 0.05LC-MS/MS20940332
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)2.85< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.19< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.89< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.28< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.35< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)00.049762673LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.434.85E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.452.85E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium