CKDdb-logoCKDdb - Molecule ID A8387

geneBIRC5, API4, IAP4
nameBaculoviral IAP repeat-containing protein 5
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BIRC5_HUMANO15392ENSG00000089685332Hs.744872603352

Functions and classifications

GOC:centriole, C:chromosome passenger complex, C:chromosome, centromeric region, C:condensed chromosome kinetochore, C:cytoplasm, C:cytoplasmic microtubule, C:cytosol, C:interphase microtubule organizing center, C:microtubule, C:midbody, C:nuclear chromosome, C:spindle, C:spindle microtubule, F:cobalt ion binding, F:cofactor binding, F:cysteine-type endopeptidase inhibitor activity, F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process, F:metal ion binding, F:microtubule binding, F:protein heterodimerization activity, F:protein homodimerization activity, F:zinc ion binding, P:apoptotic process, P:chromosome segregation, P:cytokinesis, P:establishment of chromosome localization, P:G2/M transition of mitotic cell cycle, P:mitosis, P:mitotic cell cycle, P:negative regulation of apoptotic process, P:negative regulation of endopeptidase activity, P:negative regulation of transcription, DNA-templated, P:positive regulation of cell proliferation, P:positive regulation of exit from mitosis, P:positive regulation of mitotic cell cycle, P:protein complex localization, P:protein phosphorylation, P:spindle checkpoint, P:transcription, DNA-templated, P:embryo development, P:microtubule cytoskeleton organization, P:negative regulation of neuron apoptotic process, P:cell division, P:mitotic prometaphase, P:negative regulation of transcription, DNA-dependent, P:regulation of apoptotic process, P:transcription, DNA-dependent, C:intracellular
UniProt3D-structure, Acetylation, Alternative splicing, Apoptosis, Cell cycle, Cell division, Centromere, Chromosome, Chromosome partition, Complete proteome, Cytoplasm, Cytoskeleton, Kinetochore, Metal-binding, Microtubule, Mitosis, Nucleus, Phosphoprotein, Polymorphism, Protease inhibitor, Reference proteome, Repressor, Thiol protease inhibitor, Transcription, Transcription regulation, Ubl conjugation, Zinc
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.00203RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.290.000228RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.30.00431RNA microarray19698090
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.360cDNA microarray21411733
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.220.0272736RNA microarray23935909

Compile date 08-10-2018© iMODE-CKD consortium