CKDdb-logoCKDdb - Molecule ID A8386

geneArrb2
nameBeta-arrestin-2
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARRB2_MOUSEQ91YI4ENSMUSG00000060216216869Mm.203747107941

Functions and classifications

GOC:basolateral plasma membrane, C:coated pit, C:cytoplasm, C:dendritic spine, C:endocytic vesicle, C:intracellular, C:nucleus, C:postsynaptic density, C:postsynaptic membrane, F:protein binding, F:protein kinase B binding, P:adult walking behavior, P:apoptotic DNA fragmentation, P:brain development, P:cell chemotaxis, P:desensitization of G-protein coupled receptor protein signaling pathway by arrestin, P:detection of temperature stimulus involved in sensory perception of pain, P:follicle-stimulating hormone signaling pathway, P:G-protein coupled receptor internalization, P:negative regulation of GTPase activity, P:negative regulation of interleukin-1 beta production, P:negative regulation of interleukin-12 production, P:negative regulation of interleukin-6 production, P:negative regulation of natural killer cell mediated cytotoxicity, P:negative regulation of NF-kappaB transcription factor activity, P:negative regulation of protein ubiquitination, P:negative regulation of smooth muscle cell apoptotic process, P:negative regulation of toll-like receptor signaling pathway, P:negative regulation of tumor necrosis factor production, P:positive regulation of apoptotic process, P:positive regulation of calcium ion transport, P:positive regulation of DNA biosynthetic process, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of peptidyl-tyrosine phosphorylation, P:positive regulation of protein kinase B signaling, P:positive regulation of protein ubiquitination, P:positive regulation of receptor internalization, P:positive regulation of release of cytochrome c from mitochondria, P:positive regulation of synaptic transmission, dopaminergic, P:proteasome-mediated ubiquitin-dependent protein catabolic process, P:protein transport, P:protein ubiquitination, P:regulation of androgen receptor signaling pathway, P:regulation of G-protein coupled receptor protein signaling pathway, P:regulation of protein phosphorylation, P:transcription from RNA polymerase II promoter, P:transforming growth factor beta receptor signaling pathway, C:cytoplasmic membrane-bounded vesicle, C:plasma membrane, P:positive regulation of protein kinase B signaling cascade, P:proteasomal ubiquitin-dependent protein catabolic process, P:signal transduction, C:cytoplasmic vesicle
UniProtAlternative splicing, Cell membrane, Coated pit, Complete proteome, Cytoplasm, Cytoplasmic vesicle, Hydroxylation, Membrane, Nucleus, Phosphoprotein, Protein transport, Reference proteome, Signal transduction inhibitor, Transport, Ubl conjugation
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.640.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.410.01cDNA microarray19099603
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)4.920.001RNA microarray25770168

Compile date 08-10-2018© iMODE-CKD consortium