CKDdb-logoCKDdb - Molecule ID A8385

geneANXA3, ANX3
nameAnnexin A3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANXA3_HUMANP12429ENSG00000138772306Hs.480042106490

Functions and classifications

GOC:phagocytic vesicle membrane, C:plasma membrane, C:specific granule, F:calcium ion binding, F:calcium-dependent phospholipid binding, F:phospholipase A2 inhibitor activity, P:defense response to bacterium, P:negative regulation of catalytic activity, P:neutrophil degranulation, P:phagocytosis, P:positive regulation of angiogenesis, P:positive regulation of endothelial cell migration, P:positive regulation of sequence-specific DNA binding transcription factor activity, C:cytoplasm, F:phospholipase inhibitor activity, C:axon, C:dendrite, C:neuronal cell body, P:hippocampus development, P:organ regeneration, P:positive regulation of DNA metabolic process, P:response to glucocorticoid stimulus, P:response to growth factor stimulus
UniProt3D-structure, Acetylation, Annexin, Calcium, Calcium/phospholipid-binding, Complete proteome, Direct protein sequencing, Phospholipase A2 inhibitor, Polymorphism, Reference proteome, Repeat
PADBinhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp19369687Mus musculus kidneyproximal tubule cellsCyclosporine_A_induced (Ciclosporine A in vitro model)1.48< 0.02MALDI TOF/TOF 19369687
Exp19688724Mus musculus kidneypodocytesHigh_glucose_induced (High glucose in vitro model)0.44< 0.05MALDI-TOF-MSqRT-PCR, Western blot, immunostaining19688724
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.190.00000477RNA microarray 19698090
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.470cDNA microarray 21411733
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)19.1< 0.05RNA microarray 21752957
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.42 nLC-ESI-UHR-QToF-MS/MS 23344851
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.06< 0.05RNA-seq 23757392
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)1.830.025182783LC-MS/MS 24316357
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)1.52< 0.05LC-MS/MS 24497609
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.190.010197RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium