CKDdb-logoCKDdb - Molecule ID A8384

geneAT3, SERPINC1, PRO0309
nameAntithrombin-III precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANT3_HUMANP01008ENSG00000117601462Hs.75599107300, 613118

Functions and classifications

GOC:extracellular space, C:plasma membrane, F:heparin binding, F:serine-type endopeptidase inhibitor activity, P:blood coagulation, P:negative regulation of inflammatory response, P:regulation of blood coagulation, intrinsic pathway, P:regulation of proteolysis, P:response to nutrient, P:negative regulation of endopeptidase activity, P:regulation of blood coagulation, intrinsic pathway
UniProt3D-structure, Blood coagulation, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Hemostasis, Heparin-binding, Phosphoprotein, Polymorphism, Protease inhibitor, Reference proteome, Secreted, Serine protease inhibitor, Signal, Thrombophilia
PADBinhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 1nanoLC-ESI-MS/MS 17301227
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)18.460.05RNA microarray 17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.30.00315RNA microarray 19698090
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS 20411046
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)3.70.1778LC-MS/MS 20812764
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)3.49< 0.001MALDI-TOF/TOF 21544065
Exp21659735Homo sapiens kidneymesangial cellsDiabetes (diabetic nephropathy)0.67 MALDI-TOF-MS 21659735
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.190.0046QSTAR Elite LC-MS/MS 22172726
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)1.290hybrid quadrupole-TOF, LC-MS/MS 22536212
Exp23078846Homo sapiens12kidneyperitoneal dialysateDialysis (Peritonitis)up< 0.05RP-nano-HPLC-ESI-MS/MSwestern blot, ELISA23078846
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)2.010.00003LC-MS/MSMRM23228063
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.180.000104RNA microarray 23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.260.00186RNA microarray 23291264
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)1000 1DE, MALDI 24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)1000 1DE, MALDI 24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI 24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI 24096133
Exp24790760Homo sapiens19urinewholeGlomerulonephritis (focal segmental glomerulosclerosis)5.18 nLC-MS/MS 24790760
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)2.11.00E-05LC-MS 25150443

Compile date 08-10-2018© iMODE-CKD consortium