CKDdb-logoCKDdb - Molecule ID A8383

geneAMBP, ITIL, HCP
nameAMBP protein precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AMBP_HUMANP02760ENSG00000106927259Hs.436911176870

Functions and classifications

GOC:cell surface, C:extracellular region, C:extracellular space, C:intracellular membrane-bounded organelle, C:plasma membrane, F:calcium channel inhibitor activity, F:calcium oxalate binding, F:heme binding, F:IgA binding, F:serine-type endopeptidase inhibitor activity, F:small molecule binding, P:cell adhesion, P:female pregnancy, P:heme catabolic process, P:negative regulation of immune response, P:negative regulation of JNK cascade, P:protein catabolic process, P:protein-chromophore linkage, P:viral process, P:negative regulation of endopeptidase activity, P:virus-host interaction
UniProt3D-structure, Chromophore, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Host-virus interaction, Protease inhibitor, Reference proteome, Repeat, Secreted, Serine protease inhibitor, Signal
PADBinhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16372274Homo sapiens25urinewholeGlomerulonephritis (IgA nephropathy)0.01< 0.05MALDI-TOF-MS16372274
Exp16372274Homo sapiens25urinewholeGlomerulonephritis (IgA nephropathy)0.03< 0.05MALDI-TOF-MS16372274
Exp16372274Homo sapiens25urinewholeGlomerulonephritis (IgA nephropathy)0.04< 0.05MALDI-TOF-MS16372274
Exp16549904Mus musculus10urinewholeGlomerulonephritis (membranoproliferative glomerulonephritis model)1.77 nano-LC-MS/MS16549904
Exp16549904Mus musculus10urinewholeGlomerulonephritis (membranoproliferative glomerulonephritis model)1.81 nano-LC-MS/MS16549904
Exp17242005Homo sapiens27urinewholeGlomerulonephritis (IgA nephropathy)0.16 LC-MS/MS17242005
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 1nanoLC-ESI-MS/MS17301227
Exp17327332aHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy)0.62< 0.05LC-MS/MS17327332
Exp17327332bHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy)0.2< 0.05LC-MS/MS17327332
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)4.920.05RNA microarray17579666
Exp18095357Homo sapiens38urinewholeGlomerulonephritis (IgA nephropathy)0.240.0005nano-HPLC-ESI-MS/MS18095357
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0.9 LC-MS/MS18440303
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)2.340.0454484RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.30.0000229RNA microarray19698090
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.3 LC-MS/MS20543976
Exp20639044aHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)1.81< 0.05LC-MS/MS20639044
Exp21569504aHomo sapiens50bloodplasmaChronic_Renal_Insufficiency (Chronic kidney disease)2.042.62E-05MALDI-TOF21569504
Exp21569504bHomo sapiens50bloodplasmaChronic_Renal_Insufficiency (Chronic kidney disease)3.542.74E-06MALDI-TOF21569504
Exp21569504cHomo sapiens50bloodplasmaChronic_Renal_Insufficiency (Chronic kidney disease)5.15.24E-21MALDI-TOF21569504
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)2.440.0001QSTAR Elite LC-MS/MS22172726
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.31.51E-09NGS, RNA-seq.22266139
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)1.440hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)3.41 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23464927Homo sapiens10urine Fabry (12 months of ERT)0.7<0.05QTOF MS/MS23464927
Exp24067438Homo sapiens64urinewholeAKI (AKI)6.96< 0.05LC-ESI-MS/MS24067438
Exp24067438Homo sapiens64urinewholeAKI (AKI)7.46< 0.05LC-ESI-MS/MS24067438
Exp24211404Homo sapiens16urineexosomeDiabetes (diabetic nephropathy)45.250.0000017LC-MS/MS24211404
Exp24339887Homo sapiens13urinewholeGlomerulonephritis (IgA nephropathy)1.9< 0.05GeLC-MS/MS24339887
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)0.71< 0.05LC-MS/MS24497609
Exp24761003bRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)2.38< 0.05LC-MS/MS24761003
Exp24761003cRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)1.47< 0.05LC-MS/MS24761003
Exp25032130Homo sapiens11urinewholeGlomerulonephritis (focal segmental glomerulosclerosis)4.39 nano-flow LC-MS/MS25032130
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)3.25.90E-09LC-MS25150443
Exp25578432aHomo sapiens60urinesupernatantDiabetes (type 2 diabetes without nephropathy)1.080.23LC-MS/MS25578432
Exp25578432bHomo sapiens42urinesupernatantDiabetes (type 2 diabetes with retinopathy)1.177.1E10-3LC-MS/MS25578432
Exp25578432cHomo sapiens51urinesupernatantDiabetes (diabetes with overt diabetic nephropathy)0.770.74LC-MS/MS25578432
Exp25957429Homo sapiens21urinewholeGlomerulonephritis (IgA nephropathy)0.42<0.05nano-LC-MS/MS25957429
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.32.73E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium