CKDdb-logoCKDdb - Molecule ID A8377

geneA1m, Pzp
nameAlpha-1-macroglobulin
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
A1M_RATQ63041ENSRNOG00000006709252922Rn.11295

Functions and classifications

GOC:extracellular space, F:protein complex binding, F:serine-type endopeptidase inhibitor activity, P:embryo implantation
UniProt3D-structure, Bait region, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Protease inhibitor, Reference proteome, Secreted, Serine protease inhibitor, Signal, Thioester bond
PADBinhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp20007950aRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction) 2.190.00016MALDI-TOF, LC-MS/MS  20007950
Exp20007950bRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction) 1.750.00016MALDI-TOF, LC-MS/MS  20007950
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease) 0.444.45E-09RNA microarray  20813037
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 2.160.01MALDI-TOF/TOF  21544065
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy) 0.33 nLC-ESI-UHR-QToF-MS/MS  23344851
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy) 0.47< 0.05RNA-seq  23757392
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model) 2.46< 0.05LC-MS/MS  24497609
Exp24761003dRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy) 1.85< 0.05LC-MS/MS  24761003
Exp24761003eRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy) 2.84< 0.05LC-MS/MS  24761003
Exp24761003fRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy) 2.15< 0.05LC-MS/MS  24761003

Compile date 08-30-2016© iMODE-CKD consortium