CKDdb-logoCKDdb - Molecule ID A8369

geneA1A, SERPINA1, AAT
nameAlpha-1-antitrypsin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
A1AT_HUMANP01009ENSG000001972495265Hs.525557107400, 613490

Functions and classifications

GOC:endoplasmic reticulum, C:extracellular space, C:platelet alpha granule lumen, C:proteinaceous extracellular matrix, F:serine-type endopeptidase inhibitor activity, P:acute-phase response, P:platelet activation, P:platelet degranulation, P:regulation of proteolysis
UniProt3D-structure, Acute phase, Alternative splicing, Blood coagulation, Complete proteome, Direct protein sequencing, Endoplasmic reticulum, Extracellular matrix, Glycoprotein, Hemostasis, Polymorphism, Protease inhibitor, Reference proteome, Secreted, Serine protease inhibitor, Signal
PADBinhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp16083269Rattus norvegicus10bloodserumTransplantation (Acute Renal Allograft Rejection) up< 0.05SELDI-MS (CM10, Q10), MALDI-MS/MS  16083269
Exp17081055Rattus norvegicus12urinewholeGlomerulonephritis (membranous nephropathy) up< 0.05MALDI  17081055
Exp17081055Rattus norvegicus12urinewholeGlomerulonephritis (membranous nephropathy) up< 0.05MALDI  17081055
Exp17081055Rattus norvegicus12urinewholeGlomerulonephritis (membranous nephropathy) up< 0.05MALDI  17081055
Exp17081055Rattus norvegicus12urinewholeGlomerulonephritis (membranous nephropathy) up< 0.05MALDI  17081055
Exp17242005Homo sapiens27urinewholeGlomerulonephritis (IgA nephropathy) 3.1 LC-MS/MS  17242005
Exp17327332aHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy) 2.89< 0.05LC-MS/MS  17327332
Exp17327332bHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy) 2.17< 0.05LC-MS/MS  17327332
Exp17616219Rattus norvegicus10urinewholeGlomerulonephritis (Passive Heymann Nephritis) 2.210.019MALDI-TOF-MS western blot, ELISA17616219
Exp17616219Rattus norvegicus10urinewholeGlomerulonephritis (Passive Heymann Nephritis) 3.940.016MALDI-TOF-MS western blot, ELISA17616219
Exp17616219Rattus norvegicus10urinewholeGlomerulonephritis (Passive Heymann Nephritis) 4.830.017MALDI-TOF-MS western blot, ELISA17616219
Exp18095357Homo sapiens38urinewholeGlomerulonephritis (IgA nephropathy) 8.330.0008nano-HPLC-ESI-MS/MS  18095357
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis) 3 LC-MS/MS  18440303
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.440.0476RNA microarray  19698090
Exp20007950aRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction) 2.330.0036MALDI-TOF, LC-MS/MS  20007950
Exp20007950bRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction) 2.740.0036MALDI-TOF, LC-MS/MS  20007950
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.425.80E-05RNA microarray  20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.463.59E-05RNA microarray  20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy) up MS/MS, LTQ LX linear ion trap  20093355
Exp20134395Homo sapiens9urinewholeFibrosis (Interstitial fibrosis and tubular atrophy) 3.140.045MALDI-TOF-MS, LTQ linear ion trap, capLC-ESI-ITMS/MS  20134395
Exp20348205aRattus norvegicus10bloodplasmaDiabetes (Gestational Diabetes) 1.16< 0.05RP-nano-LC-ESI-MS/MS  20348205
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)  < 0.001LC-MS/MS  20411046
Exp20639044aHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction) 1.54< 0.05LC-MS/MS  20639044
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection) 7.380.0024LC-MS/MS  20812764
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 1.310.01MALDI-TOF/TOF  21544065
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 1.84< 0.001MALDI-TOF/TOF  21544065
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 1.30.003MALDI-TOF/TOF  21544065
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy) 1.290.0001QSTAR Elite LC-MS/MS  22172726
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy) 0.237.38E-104NGS, RNA-seq.  22266139
Exp22399069Homo sapiens74urinewholeGlomerulonephritis (glomerular kidney disease) 2702.350.001MALDI-TOF-MS  22399069
Exp22399069Homo sapiens74urinewholeGlomerulonephritis (glomerular kidney disease) 63.560.003MALDI-TOF-MS  22399069
Exp22399069Homo sapiens74urinewholeGlomerulonephritis (glomerular kidney disease) 69.07< 0.001MALDI-TOF-MS  22399069
Exp22498882Homo sapiens10urinewholeGlomerulonephritis (lupus nephritis) 2.810.013ESI-Q-TOF MS/MS  22498882
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy) 1.420hybrid quadrupole-TOF, LC-MS/MS Western blot22536212
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy) 1.760hybrid quadrupole-TOF, LC-MS/MS  22536212
Exp23078846Homo sapiens12kidneyperitoneal dialysateDialysis (Peritonitis) down< 0.05RP-nano-HPLC-ESI-MS/MS western blot, ELISA23078846
Exp23143504Homo sapiens urinewholeAKI (AKI) 2210.260.03LC-MS/MS  23143504
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 1.640.00003LC-MS/MS  23228063
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy) 14.1 nLC-ESI-UHR-QToF-MS/MS  23344851
Exp23577616Homo sapiens urinewholeGlomerulonephritis (IgA nephropathy) 12.30.001MALDI-TOF-MS  23577616
Exp23577616Homo sapiens urinewholeGlomerulonephritis (IgA nephropathy) 1520.15< 0.001MALDI-TOF-MS  23577616
Exp23577616Homo sapiens urinewholeGlomerulonephritis (IgA nephropathy) 809< 0.001MALDI-TOF-MS  23577616
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy) 2.95< 0.05RNA-seq  23757392
Exp23762862Homo sapiens10kidneyperitoneal dialysateGlomerulonephritis (chronic glomerulonephritis) 55.51 +/- 13.71< 0.05LC-MS/MS  23762862
Exp24067438Homo sapiens64urinewholeAKI (AKI) 4.59< 0.05LC-ESI-MS/MS ELISA, immunoturbidimetry24067438
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy) 2.17 1DE, MALDI  24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy) 2.17 1DE, MALDI  24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy) 0.35 1DE, MALDI  24096133
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model) 4.59< 0.05LC-MS/MS  24497609
Exp24790760Homo sapiens19urinewholeGlomerulonephritis (focal segmental glomerulosclerosis) 11.52 nLC-MS/MS  24790760
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome) 2.63.90E-04LC-MS  25150443

Compile date 08-30-2016© iMODE-CKD consortium