CKDdb-logoCKDdb - Molecule ID A827B

geneAQP4
nameAquaporin 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AQP4_HUMANP55087ENSG00000171885361Hs.315369600308

Functions and classifications

GOC:basolateral plasma membrane, C:cell-cell junction, C:cytoplasm, C:external side of plasma membrane, C:integral component of plasma membrane, C:protein complex, C:T-tubule, F:porin activity, F:water channel activity, P:carbon dioxide transport, P:cellular response to estradiol stimulus, P:cellular response to interferon-gamma, P:excretion, P:female pregnancy, P:hyperosmotic salinity response, P:multicellular organismal water homeostasis, P:nervous system development, P:protein homooligomerization, P:renal water absorption, P:response to glucocorticoid, P:response to radiation, P:sensory perception of sound, P:transmembrane transport, C:membrane, F:water transmembrane transporter activity, C:integral component of membrane, F:transporter activity, C:integral to plasma membrane, C:pore complex, C:integral to membrane
UniProt3D-structure, Alternative splicing, Complete proteome, Glycoprotein, Membrane, Phosphoprotein, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport, Ion transport, Porin
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)4.89< 0.05cDNA microarrays17183245
Exp19099603bMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.450.01cDNA microarray19099603
Exp19099603bMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.720.01cDNA microarray19099603
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.210.0000472RNA microarray19698090
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)2.830.0250904RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.230.00233RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.40.0382RNA microarray19698090
Exp20485333Homo sapiens20bloodwholeGlomerulonephritis (IgA nephropathy)0.430.009035RNA microarray20485333
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.212.41E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.225.07E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.130.012895RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.150.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium