CKDdb-logoCKDdb - Molecule ID A825B

geneAQP2
nameAquaporin-CD
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AQP2_HUMANP41181ENSG00000167580359Hs.130730107777, 125800, 222000

Functions and classifications

GOC:apical plasma membrane, C:basolateral plasma membrane, C:clathrin-coated vesicle, C:early endosome, C:exocytic vesicle, C:Golgi apparatus, C:integral component of membrane, C:lysosome, C:protein complex, C:recycling endosome, C:rough endoplasmic reticulum, C:trans-Golgi network, C:transport vesicle membrane, F:glycerol transmembrane transporter activity, F:water channel activity, P:actin filament depolymerization, P:aging, P:apoptotic process, P:cell volume homeostasis, P:cellular response to copper ion, P:cellular response to mercury ion, P:cellular response to water deprivation, P:excretion, P:female pregnancy, P:hyperosmotic response, P:metanephric collecting duct development, P:positive regulation of calcium ion transport, P:renal water transport, P:response to calcium ion, P:response to glucagon, P:response to lipopolysaccharide, P:response to lithium ion, P:response to salt stress, P:response to starvation, F:transporter activity, C:integral to membrane, P:response to glucagon stimulus
UniProtCell membrane, Complete proteome, Cytoplasmic vesicle, Diabetes insipidus, Disease mutation, Glycoprotein, Golgi apparatus, Membrane, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)70.52< 0.05cDNA microarrays17183245
Exp19346236Homo sapiens10kidneycystsPolycystic_Kidney_Disease (Autosomal dominant polycystic kidney disease)00.005mRNA microarray19346236
Exp19398767Homo sapiens20kidneybiopsy sectionFibrosis (Interstitial fibrosis and tubular atrophy)0.490.000947083RNA microarray19398767
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.0000682RNA microarray19698090
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)22.63< 0.05LC-MS/MS20940332
Exp21595033bHomo sapiens14urineexosomesGlomerulonephritis (basement membrane nephropathy)0.480.01929LC-MS/MS21595033

Compile date 08-10-2018© iMODE-CKD consortium