CKDdb-logoCKDdb - Molecule ID A824B

geneAQP1, CHIP28
nameAquaporin 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AQP1_HUMANP29972ENSG00000240583358Hs.76152107776, 110450

Functions and classifications

GOC:apical plasma membrane, C:basal plasma membrane, C:brush border membrane, C:cytoplasm, C:integral component of plasma membrane, C:nuclear membrane, C:sarcolemma, C:symbiont-containing vacuole, F:ammonia transmembrane transporter activity, F:carbon dioxide transmembrane transporter activity, F:glycerol transmembrane transporter activity, F:intracellular cGMP activated cation channel activity, F:nitric oxide transmembrane transporter activity, F:potassium channel activity, F:water channel activity, P:ammonium transport, P:bicarbonate transport, P:cell volume homeostasis, P:cellular hyperosmotic response, P:cellular response to cAMP, P:cellular response to copper ion, P:cellular response to dexamethasone stimulus, P:cellular response to hydrogen peroxide, P:cellular response to hypoxia, P:cellular response to mechanical stimulus, P:cellular response to mercury ion, P:cellular response to nitric oxide, P:cellular response to retinoic acid, P:cellular response to salt stress, P:cellular response to UV, P:cerebrospinal fluid secretion, P:cGMP biosynthetic process, P:establishment or maintenance of actin cytoskeleton polarity, P:lateral ventricle development, P:maintenance of symbiont-containing vacuole by host, P:negative regulation of apoptotic process, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:odontogenesis, P:pancreatic juice secretion, P:positive regulation of angiogenesis, P:positive regulation of fibroblast proliferation, P:positive regulation of saliva secretion, P:renal water transport, P:response to drug, P:transepithelial water transport, C:integral component of membrane, F:transporter activity, C:plasma membrane, C:membrane, C:integral to plasma membrane, C:integral to membrane, C:axon terminus, C:basolateral plasma membrane, C:brush border, C:extracellular vesicular exosome, C:neuronal cell body membrane, F:potassium ion transmembrane transporter activity, P:camera-type eye morphogenesis, P:corticotropin secretion, P:glomerular filtration, P:hyperosmotic salinity response, P:lipid digestion, P:metanephric descending thin limb development, P:metanephric glomerulus vasculature development, P:metanephric proximal convoluted tubule segment 2 development, P:metanephric proximal straight tubule development, P:positive regulation of epithelial cell migration, P:positive regulation of lamellipodium assembly, P:potassium ion transmembrane transport, P:renal water absorption, P:response to estrogen stimulus, P:secretory granule organization, P:sensory perception of pain, P:wound healing
UniProt3D-structure, Alternative splicing, Blood group antigen, Complete proteome, Direct protein sequencing, Glycoprotein, Membrane, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)2.4< 0.01RNA microarray15042541
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.360cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.110.00000537RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.000453RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.858.81E-05RNA microarray20019191
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.810.012MALDI-TOF/TOF21544065
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.990.005MALDI-TOF/TOF21544065
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)5.260.035948464NGS, RNA-seq.22266139
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.190.0000265RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.410.0232RNA microarray23291264
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.72 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.48< 0.05RNA-seq23757392
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)1.62< 0.05LC-MS/MS24497609

Compile date 08-10-2018© iMODE-CKD consortium