CKDdb-logoCKDdb - Molecule ID A813B

geneAPOC3
nameApolipoprotein C-III precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOC3_HUMANP02656ENSG00000110245345Hs.73849107720, 614028

Functions and classifications

GOC:chylomicron, C:early endosome, C:intermediate-density lipoprotein particle, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:cholesterol binding, F:lipase inhibitor activity, F:phospholipid binding, P:cellular response to glucose stimulus, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:G-protein coupled receptor signaling pathway, P:high-density lipoprotein particle remodeling, P:inflammatory response, P:lipoprotein metabolic process, P:lipoprotein transport, P:negative regulation of cholesterol import, P:negative regulation of fatty acid biosynthetic process, P:negative regulation of high-density lipoprotein particle clearance, P:negative regulation of lipoprotein lipase activity, P:negative regulation of low-density lipoprotein particle clearance, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of triglyceride catabolic process, P:negative regulation of very-low-density lipoprotein particle clearance, P:negative regulation of very-low-density lipoprotein particle remodeling, P:phospholipid efflux, P:phototransduction, visible light, P:regulation of Cdc42 protein signal transduction, P:response to drug, P:response to nutrient, P:response to peptide hormone, P:retinoid metabolic process, P:reverse cholesterol transport, P:small molecule metabolic process, P:triglyceride catabolic process, P:triglyceride homeostasis, P:triglyceride mobilization, P:very-low-density lipoprotein particle assembly, C:extracellular region, F:lipid binding, P:lipid transport, C:extracellular space, C:chylomicron, P:very-low-density lipoprotein particle assembly
UniProt3D-structure, Chylomicron, Complete proteome, Direct protein sequencing, Disease mutation, Glycoprotein, Lipid degradation, Lipid metabolism, Lipid transport, Polymorphism, Reference proteome, Secreted, Sialic acid, Signal, Transport, VLDL, Lipoprotein
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.375nanoLC-ESI-MS/MS 17301227
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)18.120.05RNA microarraysqRT-PCR17579666
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)19.530.05RNA microarraysqRT-PCR17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.0000687RNA microarray 19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.457.27E-05RNA microarray 20019191
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)0.130.2314LC-MS/MS 20812764
Exp20926632aRattus norvegicus2kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)1.5< 0.05DNA microarray 20926632
Exp20926632bRattus norvegicus2kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)1.61< 0.05DNA microarray 20926632
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.22< 0.05RNA microarray 21752957
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)11.430.00594RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium