CKDdb-logoCKDdb - Molecule ID A812B

geneAPOC1, APOC1B
nameApolipoprotein C-I precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOC1_HUMANP02654ENSG00000130208341Hs.110675107710

Functions and classifications

GOC:chylomicron, C:endoplasmic reticulum, C:high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:fatty acid binding, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipase inhibitor activity, P:cholesterol efflux, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:high-density lipoprotein particle remodeling, P:lipid metabolic process, P:lipoprotein metabolic process, P:negative regulation of cholesterol transport, P:negative regulation of fatty acid biosynthetic process, P:negative regulation of lipoprotein lipase activity, P:negative regulation of phosphatidylcholine catabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:positive regulation of cholesterol esterification, P:triglyceride metabolic process, P:very-low-density lipoprotein particle assembly, P:very-low-density lipoprotein particle clearance, C:extracellular region, P:regulation of lipid transport
UniProt3D-structure, Complete proteome, Direct protein sequencing, Lipid transport, Polymorphism, Reference proteome, Secreted, Signal, Transport, VLDL, Lipoprotein
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)11.910.05RNA microarray17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.280.0017RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.002RNA microarray19698090
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)0.390.1699LC-MS/MS20812764
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.310cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.490cDNA microarray21411733
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.94< 0.05RNA microarray21752957
Exp22772331Rattus norvegicus45bloodplasmaDoxorubicin_induced (Doxorubicin-induced nephropathy)up< 0.05SELDI-TOF-MS22772331
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.88 nLC-ESI-UHR-QToF-MS/MS23344851
Exp25133636Homo sapiens22kidneyglomeruliGlomerulonephritis (IgA nephropathy (with endocapillary proliferation (E1)))3.240.0098RNA microarray25133636

Compile date 08-10-2018© iMODE-CKD consortium