CKDdb-logoCKDdb - Molecule ID A810B

geneApoa4
nameApolipoprotein A-IV
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOA4_MOUSEP06728ENSMUSG0000003208011808Mm.4533107690

Functions and classifications

GOC:chylomicron, C:cytosol, C:early endosome, C:endoplasmic reticulum lumen, C:high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:antioxidant activity, F:cholesterol transporter activity, F:copper ion binding, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:protein homodimerization activity, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron assembly, P:chylomicron remodeling, P:high-density lipoprotein particle remodeling, P:hydrogen peroxide catabolic process, P:innate immune response in mucosa, P:leukocyte cell-cell adhesion, P:lipoprotein metabolic process, P:multicellular organismal lipid catabolic process, P:negative regulation of plasma lipoprotein particle oxidation, P:phosphatidylcholine metabolic process, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of cholesterol esterification, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of lipoprotein lipase activity, P:positive regulation of triglyceride catabolic process, P:regulation of cholesterol transport, P:regulation of intestinal cholesterol absorption, P:removal of superoxide radicals, P:response to lipid hydroperoxide, P:response to stilbenoid, P:retinoid metabolic process, P:reverse cholesterol transport, P:very-low-density lipoprotein particle remodeling, C:extracellular region, F:lipid binding, P:lipid transport, C:chylomicron, P:very-low-density lipoprotein particle remodeling
UniProt3D-structure, Chylomicron, Complete proteome, HDL, Lipid transport, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Transport, Lipoprotein
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.2188nanoLC-ESI-MS/MS 17301227
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.6875nanoLC-ESI-MS/MS 17301227
Exp20007950aRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)2.240.00027MALDI-TOF, LC-MS/MS 20007950
Exp20007950bRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)2.030.00027MALDI-TOF, LC-MS/MS 20007950
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap 20093355
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS 20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS 20411046
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)2.230.5542LC-MS/MS 20812764
Exp21569504bHomo sapiens50bloodplasmaChronic_Renal_Insufficiency (Chronic kidney disease)2.294.50E-05MALDI-TOF 21569504
Exp21569504cHomo sapiens50bloodplasmaChronic_Renal_Insufficiency (Chronic kidney disease)2.366.00E-10MALDI-TOF 21569504
Exp21698285Homo sapiens124urine Fabry (naive female Fabry)2.859.09E-05CE-MS 21698285
Exp23143504Homo sapiens urinewholeAKI (AKI)544.960.01LC-MS/MS 23143504
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)4.190.00003LC-MS/MSMRM23228063
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)6.22 nLC-ESI-UHR-QToF-MS/MS 23344851
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.0062007LC-MS/MS 24172336
Exp24339887Homo sapiens13urinewholeGlomerulonephritis (IgA nephropathy)2.6< 0.05GeLC-MS/MS 24339887
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)3.42.50E-09LC-MS 25150443
Exp25666440Homo sapiens23urinesupernatantFabry (naive Fabry patients)2.680.023815nanoLC-ESI-MS/MS 25666440
Exp25957429Homo sapiens21urinewholeGlomerulonephritis (IgA nephropathy)0.64<0.05nano-LC-MS/MS 25957429
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.261.68E-03RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium