CKDdb-logoCKDdb - Molecule ID A809B

geneApoa2
nameApolipoprotein A-II
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOA2_MOUSEP09813ENSMUSG0000000568111807Mm.389209107670

Functions and classifications

GOC:chylomicron, C:cytosol, C:extracellular region, C:extracellular space, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:cholesterol binding, F:cholesterol transporter activity, F:high-density lipoprotein particle binding, F:lipase inhibitor activity, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:protein heterodimerization activity, P:acute inflammatory response, P:beta-glucoside transport, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:diacylglycerol catabolic process, P:fatty acid metabolic process, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:lipid transport, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:negative regulation of cholesterol import, P:negative regulation of cholesterol transporter activity, P:negative regulation of cytokine secretion involved in immune response, P:negative regulation of lipase activity, P:negative regulation of lipid catabolic process, P:negative regulation of very-low-density lipoprotein particle remodeling, P:organ regeneration, P:peptidyl-methionine modification, P:phosphatidylcholine biosynthetic process, P:phospholipid catabolic process, P:phospholipid efflux, P:positive regulation of cholesterol esterification, P:positive regulation of interleukin-8 biosynthetic process, P:positive regulation of lipid catabolic process, P:protein folding, P:protein oxidation, P:regulation of intestinal cholesterol absorption, P:regulation of protein stability, P:response to drug, P:response to estrogen, P:response to glucocorticoid, P:response to glucose, P:reverse cholesterol transport, P:triglyceride-rich lipoprotein particle remodeling, C:high-density lipoprotein particle, F:lipid binding
UniProtAmyloid, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disease mutation, HDL, Lipid transport, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid, Reference proteome, Secreted, Signal, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.2439nanoLC-ESI-MS/MS17301227
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)50.30.05RNA microarray17579666
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.480.01cDNA microarray19099603
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)1.920.00003LC-MS/MS23228063
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)6.73.10E-03LC-MS25150443

Compile date 08-10-2018© iMODE-CKD consortium