CKDdb-logoCKDdb - Molecule ID A7976

geneACAA1, ACAA, PTHIO
name3-ketoacyl-CoA thiolase, peroxisomal precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
THIK_HUMANP09110ENSP0000030181030Hs.643487604054

Functions and classifications

GOC:peroxisomal matrix, F:acetyl-CoA C-acyltransferase activity, F:palmitoyl-CoA oxidase activity, P:alpha-linolenic acid metabolic process, P:bile acid metabolic process, P:fatty acid beta-oxidation using acyl-CoA oxidase, P:very long-chain fatty acid metabolic process, F:transferase activity, transferring acyl groups other than amino-acyl groups
UniProt3D-structure, Acyltransferase, Alternative splicing, Complete proteome, Fatty acid metabolism, Lipid metabolism, Peroxisome, Phosphoprotein, Polymorphism, Reference proteome, Transferase, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.451.72E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)22.290.008783RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium