CKDdb-logoCKDdb - Molecule ID A7976

geneACAA1, ACAA, PTHIO
name3-ketoacyl-CoA thiolase, peroxisomal precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
THIK_HUMANP09110ENSP0000030181030Hs.643487604054

Functions and classifications

GOC:peroxisomal matrix, F:acetyl-CoA C-acyltransferase activity, F:palmitoyl-CoA oxidase activity, P:alpha-linolenic acid metabolic process, P:bile acid metabolic process, P:fatty acid beta-oxidation using acyl-CoA oxidase, P:very long-chain fatty acid metabolic process, F:transferase activity, transferring acyl groups other than amino-acyl groups
UniProt3D-structure, Acyltransferase, Alternative splicing, Complete proteome, Fatty acid metabolism, Lipid metabolism, Peroxisome, Phosphoprotein, Polymorphism, Reference proteome, Transferase, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.451.72E-05RNA microarray  20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy) down MS/MS, LTQ LX linear ion trap  20093355
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 22.290.008783RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium