CKDdb-logoCKDdb - Molecule ID A7908

geneAars
nameAlanine--tRNA ligase, cytoplasmic
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
SYAC_MOUSEQ8BGQ7ENSMUSG00000031960234734Mm.24174601065, 613287

Functions and classifications

GOC:cytoplasm, F:alanine-tRNA ligase activity, F:amino acid binding, F:aminoacyl-tRNA editing activity, F:ATP binding, F:metal ion binding, F:protein binding, F:tRNA binding, P:alanyl-tRNA aminoacylation, P:cellular response to unfolded protein, P:cerebellar Purkinje cell layer development, P:endoplasmic reticulum unfolded protein response, P:hair follicle development, P:negative regulation of neuron apoptotic process, P:neuromuscular process, P:neuromuscular process controlling balance, P:protein folding, P:regulation of translational fidelity, P:response to amino acid, P:skin development, P:tRNA modification, C:cytoplasm, F:alanine-tRNA ligase activity, F:ATP binding, F:nucleic acid binding, F:protein binding, P:alanyl-tRNA aminoacylation, P:cellular response to unfolded protein, P:cerebellar Purkinje cell layer development, P:endoplasmic reticulum unfolded protein response, P:hair follicle development, P:negative regulation of neuron apoptotic process, P:neuromuscular process, P:neuromuscular process controlling balance, P:protein folding, P:response to amino acid, P:skin development, P:tRNA modification, C:cytoplasm, F:alanine-tRNA ligase activity, F:ATP binding, F:nucleic acid binding, F:protein binding, P:alanyl-tRNA aminoacylation, P:cellular response to unfolded protein, P:cerebellar Purkinje cell layer development, P:endoplasmic reticulum unfolded protein response, P:hair follicle development, P:negative regulation of neuron apoptotic process, P:neuromuscular process, P:neuromuscular process controlling balance, P:protein folding, P:response to amino acid, P:skin development, P:tRNA modification, C:cytoplasm, F:alanine-tRNA ligase activity, F:amino acid binding, F:ATP binding, F:protein binding, F:tRNA binding, P:alanyl-tRNA aminoacylation, P:cellular response to unfolded protein, P:cerebellar Purkinje cell layer development, P:endoplasmic reticulum unfolded protein response, P:hair follicle development, P:negative regulation of neuron apoptotic process, P:neuromuscular process, P:neuromuscular process controlling balance, P:protein folding, P:response to amino acid, P:skin development, P:tRNA modification, C:cytoplasm, F:alanine-tRNA ligase activity, F:amino acid binding, F:ATP binding, F:protein binding, F:tRNA binding, P:alanyl-tRNA aminoacylation, P:cellular response to unfolded protein, P:cerebellar Purkinje cell layer development, P:endoplasmic reticulum unfolded protein response, P:hair follicle development, P:negative regulation of neuron apoptotic process, P:neuromuscular process, P:neuromuscular process controlling balance, P:protein folding, P:response to amino acid, P:skin development, P:tRNA modification, C:cytoplasm, F:alanine-tRNA ligase activity, F:ATP binding, F:nucleic acid binding, F:protein binding, P:alanyl-tRNA aminoacylation, P:cellular response to unfolded protein, P:cerebellar Purkinje cell layer development, P:endoplasmic reticulum unfolded protein response, P:hair follicle development, P:negative regulation of neuron apoptotic process, P:neuromuscular process, P:neuromuscular process controlling balance, P:protein folding, P:response to amino acid, P:skin development, P:tRNA modification
UniProtAcetylation, Aminoacyl-tRNA synthetase, ATP-binding, Complete proteome, Cytoplasm, Ligase, Metal-binding, Nucleotide-binding, Phosphoprotein, Protein biosynthesis, Reference proteome, RNA-binding, tRNA-binding, Ubl conjugation, Zinc, , , , ,
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model) 1.41< 0.05LC-MS/MS  20940332
Exp24172336Mus musculus6kidneycortexAKI (AKI) 10000.049762673LC-MS/MS  24172336
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 4.960.011745RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium