CKDdb-logoCKDdb - Molecule ID A787B

geneABCG8
nameATP-binding cassette, sub-family G, member 8
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABCG8_HUMANQ9H221ENSG0000014392164241Hs.413931210250, 605460, 611465

Functions and classifications

GOC:apical plasma membrane, C:integral component of membrane, F:ATP binding, F:ATPase activity, F:sterol transporter activity, P:ATP catabolic process, P:cholesterol efflux, P:cholesterol homeostasis, P:excretion, P:intestinal cholesterol absorption, P:negative regulation of intestinal cholesterol absorption, P:negative regulation of intestinal phytosterol absorption, P:phospholipid transport, P:response to drug, P:response to nutrient, P:transmembrane transport, C:membrane, C:integral to membrane, P:lipid metabolic process, P:sterol transport
UniProtAlternative splicing, Complete proteome, Disease mutation, Glycoprotein, Membrane, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Transport, ATP-binding, Nucleotide-binding
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.315.23E-04RNA microarray  26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.150.014904RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium