CKDdb-logoCKDdb - Molecule ID A7869

geneALDH5A1, SSADH
nameSuccinate semialdehyde dehydrogenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
SSDH_HUMANP51649ENSG000001122947915Hs.371723271980, 610045

Functions and classifications

GOC:mitochondrial matrix, F:protein homodimerization activity, F:succinate-semialdehyde dehydrogenase (NAD+) activity, F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity, P:acetate metabolic process, P:central nervous system development, P:galactosylceramide metabolic process, P:gamma-aminobutyric acid catabolic process, P:glucose metabolic process, P:glucosylceramide metabolic process, P:glutamate metabolic process, P:glutamine metabolic process, P:glutathione metabolic process, P:glycerophospholipid metabolic process, P:neurotransmitter catabolic process, P:neurotransmitter secretion, P:post-embryonic development, P:protein homotetramerization, P:respiratory electron transport chain, P:short-chain fatty acid metabolic process, P:succinate metabolic process, C:mitochondrion, F:carboxylic acid binding, F:NAD binding
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Disease mutation, Disulfide bond, Mitochondrion, NAD, Oxidoreductase, Polymorphism, Reference proteome, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.180.000702RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.548.81E-05RNA microarray20019191
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.439.12E-10NGS, RNA-seq.22266139
Exp25279147Homo sapiens12kidneybiopsy sectionGlomerulonephritis (IgA nephropathy)0.55< 0.05MALDI TOF/TOF25279147

Compile date 08-10-2018© iMODE-CKD consortium