CKDdb-logoCKDdb - Molecule ID A783B

geneABCG1, ABC8, WHT1
nameATP-binding cassette
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABCG1_HUMANP45844ENSG000001601799619Hs.124649603076

Functions and classifications

GOC:endoplasmic reticulum membrane, C:external side of plasma membrane, C:Golgi apparatus, C:Golgi membrane, C:integral component of plasma membrane, C:mitochondrion, C:recycling endosome, F:ADP binding, F:ATP binding, F:cholesterol binding, F:cholesterol transporter activity, F:glycoprotein transporter activity, F:phospholipid binding, F:phospholipid transporter activity, F:protein homodimerization activity, F:sterol-transporting ATPase activity, F:toxin transporter activity, P:amyloid precursor protein catabolic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:detection of hormone stimulus, P:glycoprotein transport, P:high-density lipoprotein particle remodeling, P:intracellular cholesterol transport, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:negative regulation of cholesterol storage, P:negative regulation of macrophage derived foam cell differentiation, P:phospholipid efflux, P:phospholipid homeostasis, P:positive regulation of cholesterol biosynthetic process, P:positive regulation of cholesterol efflux, P:regulation of cholesterol esterification, P:regulation of transcription, DNA-templated, P:response to high density lipoprotein particle, P:response to lipid, P:reverse cholesterol transport, F:ATPase activity, P:ATP catabolic process, C:membrane, P:transport, C:external side of plasma membrane, P:negative regulation of lipid storage, C:integral to plasma membrane, P:regulation of transcription, DNA-dependent, P:response to high density lipoprotein particle stimulus, C:integral to membrane, C:integral to membrane
UniProtAlternative splicing, ATP-binding, Complete proteome, Endoplasmic reticulum, Golgi apparatus, Lipid transport, Lipoprotein, Membrane, Mitochondrion, Nucleotide-binding, Palmitate, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis) 4< 0.05RNA microarray  18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis) 2.8< 0.05RNA microarray  18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.270.0000663RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.310.00000849RNA microarray  19698090

Compile date 08-30-2016© iMODE-CKD consortium