CKDdb-logoCKDdb - Molecule ID A778B

geneABCB11, BSEP
nameBile salt export pump
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABCBB_HUMANO95342ENSG000000737348647Hs.658439601847, 603201, 605479

Functions and classifications

GOC:apical plasma membrane, C:Golgi membrane, C:integral component of plasma membrane, C:intercellular canaliculus, F:ATP binding, F:bile acid-exporting ATPase activity, F:canalicular bile acid transmembrane transporter activity, F:sodium-exporting ATPase activity, phosphorylative mechanism, P:bile acid biosynthetic process, C:apical part of cell, C:membrane, F:ATPase activity, P:ATP catabolic process, C:apical part of cell, C:integral component of membrane, F:ATPase activity, coupled to transmembrane movement of substances, P:ATP catabolic process, C:integral component of membrane, C:integral to plasma membrane, C:integral to membrane, C:integral to membrane
UniProtATP-binding, Complete proteome, Disease mutation, Glycoprotein, Intrahepatic cholestasis, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.380.0198RNA microarray  19698090
Exp24172336Mus musculus6kidneycortexAKI (AKI) 10000.018792802LC-MS/MS  24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.352.65E-03RNA microarray  26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.160.013999RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium