CKDdb-logoCKDdb - Molecule ID A764B

geneABC-1, ABCA1, ABC1
nameATP-binding cassette
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABCA1_HUMANO95477ENSG0000016502919Hs.659274205400, 600046, 604091

Functions and classifications

GOC:cell surface, C:Golgi apparatus, C:integral component of plasma membrane, C:membrane raft, C:phagocytic vesicle, F:anion transmembrane transporter activity, F:apolipoprotein A-I receptor activity, F:ATP binding, F:ATPase activity, F:cholesterol binding, F:cholesterol transporter activity, F:phospholipid binding, F:phospholipid transporter activity, P:ATP catabolic process, P:cellular lipid metabolic process, P:cellular response to cholesterol, P:cellular response to lipopolysaccharide, P:cellular response to retinoic acid, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:endosomal transport, P:G-protein coupled receptor signaling pathway, P:high-density lipoprotein particle assembly, P:interleukin-1 beta secretion, P:intracellular cholesterol transport, P:lipoprotein metabolic process, P:lysosome organization, P:negative regulation of cholesterol storage, P:negative regulation of macrophage derived foam cell differentiation, P:peptide secretion, P:phagocytosis, engulfment, P:phospholipid efflux, P:phospholipid homeostasis, P:phospholipid translocation, P:platelet dense granule organization, P:positive regulation of cAMP biosynthetic process, P:positive regulation of cholesterol efflux, P:protein lipidation, P:regulation of Cdc42 protein signal transduction, P:response to drug, P:response to laminar fluid shear stress, P:response to low-density lipoprotein particle, P:response to nutrient, P:reverse cholesterol transport, P:ion transmembrane transport, C:Golgi apparatus, C:integral to plasma membrane, P:response to low-density lipoprotein particle stimulus
UniProtAtherosclerosis, ATP-binding, Cholesterol metabolism, Complete proteome, Disease mutation, Disulfide bond, Glycoprotein, Lipid metabolism, Lipoprotein, Membrane, Nucleotide-binding, Palmitate, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Steroid metabolism, Sterol metabolism, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 2.150.04cDNA microarray  19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.340.00057RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.450.000308RNA microarray  19698090
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy) 2.28< 0.05RNA-seq  23757392
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease) 0.480.0499404RNA microarray  23935909
Exp25133636Homo sapiens22kidneyglomeruliGlomerulonephritis (IgA nephropathy (with endocapillary proliferation (E1))) 2.270RNA microarray  25133636
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD) 0.431.46E-03RNA microarray  26317775

Compile date 08-30-2016© iMODE-CKD consortium