CKDdb-logoCKDdb - Molecule ID A7566

geneCad, Cad-pending
nameCAD protein
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PYR1_MOUSEB2RQC6ENSMUSG0000001362969719Mm.305535114010

Functions and classifications

GOC:cytosol, C:neuronal cell body, C:nuclear matrix, C:protein complex, C:terminal bouton, F:amino acid binding, F:aspartate carbamoyltransferase activity, F:ATP binding, F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, F:dihydroorotase activity, F:zinc ion binding, P:'de novo' pyrimidine nucleobase biosynthetic process, P:'de novo' UMP biosynthetic process, P:carbamoyl phosphate biosynthetic process, P:cellular response to drug, P:cellular response to epidermal growth factor stimulus, P:drug metabolic process, P:embryo development, P:female pregnancy, P:glutamine catabolic process, P:lactation, P:organ regeneration, P:response to amine, P:response to caffeine, P:response to cortisol, P:response to testosterone, P:UTP biosynthetic process, F:amino acid binding, F:aspartate carbamoyltransferase activity, F:ATP binding, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, F:metal ion binding, P:'de novo' pyrimidine nucleobase biosynthetic process, P:carbamoyl phosphate biosynthetic process, P:glutamine catabolic process, F:ATP binding, F:catalytic activity, F:metal ion binding, P:carbamoyl phosphate biosynthetic process, P:glutamine catabolic process, F:amino acid binding, F:ATP binding, F:carboxyl- or carbamoyltransferase activity, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, F:metal ion binding, P:carbamoyl phosphate biosynthetic process, P:glutamine catabolic process, F:ATP binding, F:catalytic activity, F:metal ion binding, P:carbamoyl phosphate biosynthetic process, P:glutamine catabolic process, F:ATP binding, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, F:metal ion binding, P:nitrogen compound metabolic process, C:cytosol, C:neuronal cell body, C:nuclear matrix, C:protein complex, C:terminal bouton, F:amino acid binding, F:aspartate carbamoyltransferase activity, F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, F:dihydroorotase activity, P:'de novo' pyrimidine nucleobase biosynthetic process, P:cellular response to drug, P:cellular response to epidermal growth factor stimulus, P:drug metabolic process, P:embryo development, P:female pregnancy, P:glutamine metabolic process, P:lactation, P:organ regeneration, P:response to amine, P:response to caffeine, P:response to cortisol, P:response to testosterone, P:UTP biosynthetic process, F:amino acid binding, F:aspartate carbamoyltransferase activity, P:cellular amino acid metabolic process, F:amino acid binding, F:aspartate carbamoyltransferase activity, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, P:'de novo' pyrimidine nucleobase biosynthetic process, P:cellular amino acid metabolic process
UniProtAcetylation, Allosteric enzyme, Alternative splicing, ATP-binding, Complete proteome, Cytoplasm, Hydrolase, Ligase, Metal-binding, Multifunctional enzyme, Nucleotide-binding, Nucleus, Phosphoprotein, Pyrimidine biosynthesis, Reference proteome, Repeat, Transferase, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)0.42< 0.05LC-MS/MS19845401
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.440.00000763RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium