CKDdb-logoCKDdb - Molecule ID A7560

geneADSS, ADSS2
nameAdenylosuccinate synthetase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PURA2_HUMANP30520ENSG00000035687159Hs.498313103060

Functions and classifications

GOC:cytosol, C:plasma membrane, F:adenylosuccinate synthase activity, F:GTP binding, F:magnesium ion binding, F:phosphate ion binding, P:'de novo' AMP biosynthetic process, P:AMP biosynthetic process, P:aspartate metabolic process, P:cellular response to electrical stimulus, P:GTP catabolic process, P:immune system process, P:IMP metabolic process, P:purine nucleobase metabolic process, P:response to ammonium ion, P:response to purine-containing compound, C:cytoplasm, P:purine nucleotide biosynthetic process
UniProt3D-structure, Complete proteome, Cytoplasm, GTP-binding, Ligase, Magnesium, Metal-binding, Nucleotide-binding, Polymorphism, Purine biosynthesis, Reference proteome, Acetylation
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp23809614aHomo sapiens83bloodwholeChronic_Renal_Insufficiency (End-stage renal failure)0.144.02E-13RNA microarray23809614
Exp23809614bHomo sapiens32bloodwholeChronic_Renal_Insufficiency (End-stage renal failure)0.052.72E-11RNA microarray23809614
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.860.019889449LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.489.08E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.190.00656RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium