CKDdb-logoCKDdb - Molecule ID A7558

geneATIC, PURH
nameBifunctional purine biosynthesis protein PURH
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PUR9_HUMANP31939ENSP00000236959471Hs.90280601731, 608688

Functions and classifications

GOC:cytosol, C:mitochondrion, F:IMP cyclohydrolase activity, F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity, P:'de novo' IMP biosynthetic process, P:brainstem development, P:cerebellum development, P:cerebral cortex development, P:dihydrofolate metabolic process, P:nucleoside metabolic process, P:organ regeneration, P:purine nucleobase metabolic process, P:purine ribonucleoside monophosphate biosynthetic process, P:response to inorganic substance, P:tetrahydrofolate biosynthetic process, P:purine nucleotide biosynthetic process, P:ribonucleotide metabolic process
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, Epilepsy, Hydrolase, Multifunctional enzyme, Polymorphism, Purine biosynthesis, Reference proteome, Transferase
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)2.25< 0.05LC-MS/MS19845401
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.44< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium