CKDdb-logoCKDdb - Molecule ID A7476

geneALPL
nameAlkaline phosphatase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PPBT_HUMANP05186ENSG00000162551249Hs.75431146300, 171760, 241500, 241510

Functions and classifications

GOC:anchored component of membrane, C:extracellular matrix, C:extracellular membrane-bounded organelle, C:extracellular space, C:integral component of membrane, C:plasma membrane, F:alkaline phosphatase activity, F:metal ion binding, F:pyrophosphatase activity, P:cellular response to organic cyclic compound, P:cementum mineralization, P:developmental process involved in reproduction, P:endochondral ossification, P:response to antibiotic, P:response to glucocorticoid, P:response to lipopolysaccharide, P:response to vitamin D, P:skeletal system development, P:dephosphorylation, F:phosphatase activity, C:anchored to membrane, C:integral to membrane, P:response to glucocorticoid stimulus
UniProtAlternative splicing, Biomineralization, Cell membrane, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, GPI-anchor, Hydrolase, Lipoprotein, Magnesium, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Signal, Transmembrane, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.360.02cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.064.72E-10RNA microarray19698090
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)0.482.88E-07RNA microarray20813037
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.920.027MALDI-TOF/TOF21544065
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)2.95< 0.05RNA microarray21752957
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.94 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.47< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium