CKDdb-logoCKDdb - Molecule ID A737H

geneADCYAP1, PACAP
namePituitary adenylate cyclase activating polypeptide precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PACA_HUMANP18509ENSG00000141433116Hs.531719102980

Functions and classifications

GOC:extracellular region, C:extracellular space, C:terminal bouton, F:neuropeptide hormone activity, F:peptide hormone receptor binding, F:pituitary adenylate cyclase activating polypeptide activity, F:receptor signaling protein activity, P:activation of adenylate cyclase activity, P:ATP metabolic process, P:behavioral fear response, P:cAMP-mediated signaling, P:cell-cell signaling, P:cellular response to glucocorticoid stimulus, P:female pregnancy, P:histamine secretion, P:negative regulation of acute inflammatory response to antigenic stimulus, P:negative regulation of acute inflammatory response to non-antigenic stimulus, P:negative regulation of cell cycle, P:negative regulation of glial cell proliferation, P:negative regulation of muscle cell apoptotic process, P:negative regulation of potassium ion transport, P:negative regulation of Rho GTPase activity, P:neuron projection development, P:neuropeptide signaling pathway, P:neurotrophin TRK receptor signaling pathway, P:ovarian follicle development, P:pituitary gland development, P:positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway, P:positive regulation of cell proliferation, P:positive regulation of cytosolic calcium ion concentration, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of growth hormone secretion, P:positive regulation of interleukin-6 production, P:positive regulation of neuron projection development, P:positive regulation of protein kinase activity, P:positive regulation of Rap GTPase activity, P:positive regulation of somatostatin secretion, P:positive regulation of synaptic transmission, glutamatergic, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of vasodilation, P:regulation of G-protein coupled receptor protein signaling pathway, P:regulation of oligodendrocyte progenitor proliferation, P:regulation of postsynaptic membrane potential, P:regulation of protein localization, P:response to ethanol, P:response to starvation, P:sensory perception of pain, C:extracellular space, C:extracellular region, P:nerve growth factor receptor signaling pathway
UniProt3D-structure, Amidation, Cleavage on pair of basic residues, Complete proteome, Hormone, Neurogenesis, Polymorphism, Reference proteome, Secreted, Signal
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.0258RNA microarray19698090
Exp24281856aRattus norvegicus urinewholehealthy (healthy)0.78 +/- 0.39 MALDI-TOF24281856
Exp24281856bRattus norvegicus urinewholeDiabetes (diabetic nephropathy)0.9 +/- 0.07 MALDI-TOF24281856
Exp24281856cRattus norvegicus urinewholeDiabetes (diabetic nephropathy)1.32 +/- 0.065 MALDI-TOF24281856
Exp24281856dRattus norvegicus urinewholeDiabetes (diabetic nephropathy)1.39 +/- 0.3 MALDI-TOF24281856
Exp24281856eRattus norvegicus urinewholehealthy (healthy)1.27 +/- 0.71 MALDI-TOF24281856

Compile date 08-10-2018© iMODE-CKD consortium