CKDdb-logoCKDdb - Molecule ID A7311

genePCK1, PEPCK1
namePhosphoenolpyruvate carboxykinase, cytosolic [GTP]
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PCKGC_HUMANP35558ENSG000001242535105Hs.1872261680, 614168

Functions and classifications

GOC:cytosol, F:carboxylic acid binding, F:GDP binding, F:GTP binding, F:magnesium ion binding, F:manganese ion binding, F:phosphoenolpyruvate carboxykinase (GTP) activity, P:drug metabolic process, P:gluconeogenesis, P:glucose homeostasis, P:glycerol biosynthetic process from pyruvate, P:internal protein amino acid acetylation, P:oxaloacetate metabolic process, P:response to activity, P:response to insulin, F:kinase activity, F:phosphoenolpyruvate carboxykinase activity, P:response to insulin stimulus
UniProt3D-structure, Acetylation, Complete proteome, Cytoplasm, Decarboxylase, Gluconeogenesis, GTP-binding, Lyase, Manganese, Metal-binding, Nucleotide-binding, Polymorphism, Reference proteome, Ubl conjugation, Kinase, Pyruvate, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.6< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.64< 0.05cDNA microarray17003339
Exp19099603bMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.470.01cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.120.02cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.380cDNA microarray19099603
Exp19346236Homo sapiens10kidneycystsPolycystic_Kidney_Disease (Autosomal dominant polycystic kidney disease)00.005mRNA microarray19346236
Exp19346236Homo sapiens10kidneycystsPolycystic_Kidney_Disease (Autosomal dominant polycystic kidney disease)00.005mRNA microarray19346236
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.248.24E-06RNA microarray20019191
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)0.371.36E-08RNA microarray20813037
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)2.770.004MALDI-TOF/TOF21544065
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.650.03MALDI-TOF/TOF21544065
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.132.20E-06Nano RP-LC, MALDI-TOF22061828
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.261.60E-03Nano RP-LC, MALDI-TOF22061828
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)3.810.0401125RNA microarray23935909

Compile date 08-10-2018© iMODE-CKD consortium