CKDdb-logoCKDdb - Molecule ID A7262

geneAldh18a1, P5cs, Pycs
nameDelta-1-pyrroline-5-carboxylate synthase
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
P5CS_MOUSEQ9Z110ENSMUSG0000002500756454Mm.233117138250, 219150, 612652

Functions and classifications

GOC:mitochondrial inner membrane, C:mitochondrion, F:ATP binding, F:glutamate 5-kinase activity, F:glutamate-5-semialdehyde dehydrogenase activity, P:cellular amino acid biosynthetic process, P:citrulline biosynthetic process, P:glutamate metabolic process, P:L-proline biosynthetic process, P:ornithine biosynthetic process, P:proline biosynthetic process, P:phosphorylation
UniProtAlternative splicing, Amino-acid biosynthesis, ATP-binding, Complete proteome, Kinase, Membrane, Mitochondrion, Mitochondrion inner membrane, Multifunctional enzyme, NADP, Nucleotide-binding, Oxidoreductase, Proline biosynthesis, Reference proteome, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.820.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.280.01cDNA microarray19099603
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy)4.45< 0.05LC-MS/MS19845401
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.81< 0.05RNA microarray21752957
Exp24316357Rattus norvegicus kidneyproximal tubule cellsureteral_obstruction (kidney obstruction in vitro model)1.950.017294421LC-MS/MS24316357
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.56.60E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium