CKDdb-logoCKDdb - Molecule ID A7228

geneBCKDHB
name2-oxoisovalerate dehydrogenase beta subunit
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ODBB_HUMANP21953ENSG00000083123594Hs.654441248600, 248611

Functions and classifications

GOC:mitochondrial alpha-ketoglutarate dehydrogenase complex, F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity, F:alpha-ketoacid dehydrogenase activity, F:carboxy-lyase activity, P:branched-chain amino acid catabolic process, P:cellular nitrogen compound metabolic process, P:response to cAMP, P:response to glucocorticoid, P:response to nutrient, P:oxidation-reduction process, F:catalytic activity, P:response to glucocorticoid stimulus
UniProt3D-structure, Acetylation, Complete proteome, Direct protein sequencing, Disease mutation, Maple syrup urine disease, Mitochondrion, Oxidoreductase, Polymorphism, Reference proteome, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.480.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.420cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.00227RNA microarray19698090
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.440.00782RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium