CKDdb-logoCKDdb - Molecule ID A7085

geneADI1, MTCBP1, HMFT1638
name1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
MTND_HUMANQ9BV57ENSG0000018255155256Hs.502773613400

Functions and classifications

GOC:cytosol, C:Golgi apparatus, C:nucleus, C:plasma membrane, F:acireductone dioxygenase [iron(II)-requiring] activity, F:iron ion binding, P:L-methionine salvage from methylthioadenosine, P:polyamine metabolic process, F:metal ion binding
UniProtAlternative splicing, Amino-acid biosynthesis, Cell membrane, Complete proteome, Cytoplasm, Dioxygenase, Direct protein sequencing, Iron, Membrane, Metal-binding, Methionine biosynthesis, Nucleus, Oxidoreductase, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.030.0112RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.520.000113537RNA microarray20019191
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)4.730.014052RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium