CKDdb-logoCKDdb - Molecule ID A7010

geneAms2, LOC100363915
nameS-adenosylmethionine synthase isoform type-2
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
METK2_RATP18298ENSRNOG00000013520171347Rn.144658

Functions and classifications

GOC:cytosol, F:amino acid binding, F:ATP binding, F:metal ion binding, F:methionine adenosyltransferase activity, P:circadian rhythm, P:one-carbon metabolic process, P:response to cAMP, P:response to drug, P:response to hormone, P:response to light stimulus, P:S-adenosylmethionine biosynthetic process, P:methanogenesis, P:response to hormone stimulus, F:ATP binding, F:metal ion binding, F:methionine adenosyltransferase activity, P:one-carbon metabolic process, P:S-adenosylmethionine biosynthetic process, F:ATP binding, F:metal ion binding, F:methionine adenosyltransferase activity, P:one-carbon metabolic process, P:S-adenosylmethionine biosynthetic process, P:methanogenesis, F:ATP binding, F:metal ion binding, F:methionine adenosyltransferase activity, P:methanogenesis, P:one-carbon metabolic process, P:S-adenosylmethionine biosynthetic process
UniProtAcetylation, ATP-binding, Cobalt, Complete proteome, Magnesium, Metal-binding, Nucleotide-binding, One-carbon metabolism, Phosphoprotein, Potassium, Reference proteome, Transferase, ATP-binding, Complete proteome, Magnesium, Metal-binding, Nucleotide-binding, One-carbon metabolism, Potassium, Reference proteome, Transferase, ,
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.364.00E-05Nano RP-LC, MALDI-TOF22061828
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.150.0000133RNA microarray23291264
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.37< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)0.49< 0.05RNA-seq23757392
Exp25449168Rattus norvegicus pancreasbeta-cells (INS-1 cell line)Diabetes (pancreatic beta-cell function)0.54 LC-MS/MS25449168

Compile date 08-10-2018© iMODE-CKD consortium