CKDdb-logoCKDdb - Molecule ID A6995

geneABCB4, MDR3, PGY3
nameMultidrug resistance protein 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
MDR3_HUMANP21439ENSG000000054715244Hs.654403171060, 600803, 602347, 614972

Functions and classifications

GOC:apical plasma membrane, C:Golgi membrane, C:integral component of plasma membrane, C:intercellular canaliculus, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:xenobiotic-transporting ATPase activity, P:cellular lipid metabolic process, P:drug transmembrane transport, P:xenobiotic transport, P:response to xenobiotic stimulus, C:integral component of membrane, P:ATP catabolic process, F:ATPase activity, P:ATP catabolic process, C:membrane, C:integral to plasma membrane, P:response to drug, P:response to glucocorticoid stimulus, C:integral to membrane, C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of substances, P:response to glucocorticoid stimulus, C:integral component of membrane
UniProtAlternative splicing, ATP-binding, Cell membrane, Complete proteome, Disease mutation, Glycoprotein, Hydrolase, Intrahepatic cholestasis, Membrane, Nucleotide-binding, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.260.00573RNA microarray  19698090
Exp20348205aRattus norvegicus10bloodplasmaDiabetes (Gestational Diabetes) 1.12< 0.01RP-nano-LC-ESI-MS/MS  20348205
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy) 2< 0.05RNA-seq  23757392

Compile date 08-30-2016© iMODE-CKD consortium