CKDdb-logoCKDdb - Molecule ID A6993

geneABCB1, MDR1, PGY1
nameMultidrug resistance protein 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
MDR1_HUMANP08183ENSG000000855635243Hs.489033171050, 612244, 120080

Functions and classifications

GOC:apical plasma membrane, C:cell surface, C:Golgi membrane, C:integral component of membrane, C:intercellular canaliculus, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:xenobiotic-transporting ATPase activity, P:drug transmembrane transport, P:G2/M transition of mitotic cell cycle, P:stem cell proliferation, P:xenobiotic transport, C:integral component of membrane, P:ATP catabolic process, F:ATPase activity, P:ATP catabolic process, C:integral to membrane, P:stem cell proliferation, C:integral to membrane
UniProtATP-binding, Cell membrane, Complete proteome, Glycoprotein, Hydrolase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.40.0209393RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.570.000486783RNA microarray20019191
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.41< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium