CKDdb-logoCKDdb - Molecule ID A693C

geneATP6V0A4, ATP6N1B, ATP6N2
nameVacuolar proton translocating ATPase 116 kDa subunit a isoform 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
VPP4_HUMANQ9HBG4ENSG0000010592950617Hs.98967602722, 605239

Functions and classifications

GOC:apical plasma membrane, C:brush border membrane, C:endosome membrane, C:integral component of membrane, C:lysosomal membrane, C:phagocytic vesicle membrane, C:vacuolar proton-transporting V-type ATPase, V0 domain, F:hydrogen ion transmembrane transporter activity, P:ATP hydrolysis coupled proton transport, P:cellular iron ion homeostasis, P:excretion, P:insulin receptor signaling pathway, P:interaction with host, P:ossification, P:phagosome maturation, P:proton transport, P:regulation of pH, P:sensory perception of sound, P:transferrin transport, P:transmembrane transport, C:proton-transporting V-type ATPase, V0 domain, P:ATP hydrolysis coupled proton transport, C:integral to membrane, C:proton-transporting two-sector ATPase complex, proton-transporting domain
UniProtCell membrane, Complete proteome, Disease mutation, Hydrogen ion transport, Ion transport, Membrane, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.460cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.0035RNA microarray19698090
Exp19836472Mus musculus kidneytubule cellsDiabetes (Diabetic Nephropathy)0.31 LC-MS/MS19836472

Compile date 08-10-2018© iMODE-CKD consortium