CKDdb-logoCKDdb - Molecule ID A6928

geneAlox15b, Alox15b
nameArachidonate 15-lipoxygenase B
speciesRattus norvegicus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LX15B_RATQ8K4F2ENSRNOG00000007778266604Rn.86437603697

Functions and classifications

GOC:cytoskeleton, C:cytosol, C:extrinsic component of membrane, C:intracellular, C:nucleus, C:plasma membrane, F:arachidonate 15-lipoxygenase activity, F:calcium ion binding, F:iron ion binding, F:lipid binding, P:arachidonic acid metabolic process, P:hepoxilin biosynthetic process, P:lipoxygenase pathway, C:cytoplasm, F:lipoxygenase activity, P:leukotriene biosynthetic process, P:negative regulation of cell cycle, P:negative regulation of cell proliferation, P:negative regulation of growth, C:cytoskeleton, C:cytosol, C:plasma membrane, F:arachidonate 15-lipoxygenase activity, F:arachidonate 8(S)-lipoxygenase activity, F:iron ion binding, F:linoleate 13S-lipoxygenase activity, P:arachidonic acid metabolic process, P:linoleic acid metabolic process, P:lipoxygenase pathway, P:negative regulation of cell cycle, P:negative regulation of cell proliferation, P:negative regulation of growth, P:positive regulation of chemokine secretion, P:positive regulation of keratinocyte differentiation, P:positive regulation of macrophage derived foam cell differentiation, P:positive regulation of peroxisome proliferator activated receptor signaling pathway, F:lipoxygenase activity, P:leukotriene metabolic process
UniProtCalcium, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Dioxygenase, Iron, Lipid metabolism, Lipid-binding, Membrane, Metal-binding, Nucleus, Oxidoreductase, Reference proteome, Leukotriene biosynthesis, Complete proteome, Dioxygenase, Iron, Metal-binding, Oxidoreductase, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp20926632aRattus norvegicus2kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.7< 0.05DNA microarrayRT-PCR20926632
Exp20926632bRattus norvegicus2kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.53< 0.05DNA microarray 20926632
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)5.25< 0.05RNA-seq 23757392
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.377.75E-04RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium