CKDdb-logoCKDdb - Molecule ID A6927

geneALOX12B
nameArachidonate 12-lipoxygenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LX12B_HUMANO75342ENSG00000179477242Hs.136574242100, 603741

Functions and classifications

GOC:cytosol, F:arachidonate 12-lipoxygenase activity, F:iron ion binding, F:linoleate 9S-lipoxygenase activity, P:arachidonic acid metabolic process, P:ceramide biosynthetic process, P:establishment of skin barrier, P:hepoxilin biosynthetic process, P:linoleic acid metabolic process, P:lipoxygenase pathway, P:positive regulation of gene expression, P:positive regulation of MAPK cascade, P:positive regulation of mucus secretion, P:protein lipidation, F:lipoxygenase activity, P:epidermis development, P:leukotriene biosynthetic process, P:lipid metabolic process
UniProtComplete proteome, Cytoplasm, Dioxygenase, Disease mutation, Fatty acid metabolism, Ichthyosis, Iron, Lipid metabolism, Metal-binding, Oxidoreductase, Polymorphism, Reference proteome, Leukotriene biosynthesis
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.000367RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium