CKDdb-logoCKDdb - Molecule ID A6914

geneAlox5
nameArachidonate 5-lipoxygenase
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LOX5_MOUSEP48999ENSMUSG0000002570111689Mm.41072152390

Functions and classifications

GOC:cytoplasm, C:cytosol, C:nuclear envelope lumen, C:nuclear matrix, C:nuclear membrane, C:nucleus, F:arachidonate 5-lipoxygenase activity, F:iron ion binding, F:protein binding, P:inflammatory response, P:leukotriene biosynthetic process, P:leukotriene metabolic process, P:leukotriene production involved in inflammatory response, C:cytoplasm, C:nucleus, F:iron ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, F:protein binding, P:inflammatory response, P:leukotriene biosynthetic process, P:leukotriene metabolic process, P:leukotriene production involved in inflammatory response, C:cytoplasm, C:nucleus, F:iron ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, F:protein binding, P:inflammatory response, P:leukotriene biosynthetic process, P:leukotriene metabolic process, P:leukotriene production involved in inflammatory response, C:cytoplasm, C:nucleus, F:iron ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, F:protein binding, P:inflammatory response, P:leukotriene biosynthetic process, P:leukotriene metabolic process, P:leukotriene production involved in inflammatory response, C:cytoplasm, C:nucleus, F:iron ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, F:protein binding, P:inflammatory response, P:leukotriene biosynthetic process, P:leukotriene metabolic process, P:leukotriene production involved in inflammatory response, C:cytoplasm, C:nucleus, F:metal ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, F:protein binding, P:inflammatory response, P:leukotriene biosynthetic process, P:leukotriene metabolic process, P:leukotriene production involved in inflammatory response
UniProtCalcium, Complete proteome, Cytoplasm, Dioxygenase, Iron, Leukotriene biosynthesis, Membrane, Metal-binding, Nucleus, Oxidoreductase, Phosphoprotein, Reference proteome
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.390.000113537RNA microarray20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)30889.95< 0.05RNA microarray21752957
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.40.002222985NGS, RNA-seq.22266139
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)3.57< 0.05RNA-seq23757392
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.140.00000905RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium