CKDdb-logoCKDdb - Molecule ID A6853

geneKLK1, KALLIKREIN
nameKallikrein 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
KLK1_HUMANP06870ENSG000001677483816Hs.123107147910

Functions and classifications

GOC:nucleus, F:serine-type endopeptidase activity, P:proteolysis, F:catalytic activity, P:metabolic process
UniProt3D-structure, Alternative splicing, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Hydrolase, Polymorphism, Protease, Reference proteome, Serine protease, Signal, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16549904Mus musculus10urinewholeGlomerulonephritis (membranoproliferative glomerulonephritis model)1.31 nano-LC-MS/MS16549904
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.72< 0.05cDNA microarray17003339
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)3.4< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)3.86< 0.05cDNA microarray17003339
Exp17881425Mus musculus12urinewholeGlomerulonephritis (focal segmental glomerulosclerosis)  MALDI-TOF-MS17881425
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0.53 LC-MS/MS18440303
Exp19099603bMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.450.01cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.130.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.180.01cDNA microarray19099603
Exp19346236Homo sapiens10kidneycystsPolycystic_Kidney_Disease (Autosomal dominant polycystic kidney disease)0.010.005mRNA microarray19346236
Exp19346236Homo sapiens10kidneycystsPolycystic_Kidney_Disease (Autosomal dominant polycystic kidney disease)0.110.005mRNA microarray19346236
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.480.0277RNA microarray19698090
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.3 LC-MS/MS20543976
Exp21354196Mus musculus24urinewholeCyclosporine_A_induced (cyclosporine A nephrotoxicity)2.11 MS/MS21354196
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.17< 0.05RNA microarray21752957
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)0.730.02hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23506792aMus musculus10urinewholeDiclofenac_induced (diclofenac-induced renal injury) < 0.05MALDI-TOF MS23506792
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.31< 0.05RNA-seq23757392
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.46< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)0.48< 0.05RNA-seq23757392
Exp24096133aHomo sapiens10urine>10kDaDiabetes (type 1 diabetes without retinopathy or nephropathy)0 1DE, MALDI24096133
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)0 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)0 1DE, MALDI24096133
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.670.012708856LC-MS/MS24172336
Exp24886809Mus musculus6pancreaswholeDiabetes (type 2 diabetes)1.68< 0.05MALDI-TOF24886809
Exp25957429Homo sapiens21urinewholeGlomerulonephritis (IgA nephropathy)0.28<0.05nano-LC-MS/MS25957429
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)51.630.002621RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium