CKDdb-logoCKDdb - Molecule ID A6852

geneCAMKK2, CAMKKB, CAMKK BETA-3
nameCalcium/calmodulin-dependent protein kinase kinase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
KKCC2_HUMANQ96RR4ENSG0000011093110645Hs.297343615002

Functions and classifications

GOC:cell projection, C:cytoplasm, C:nucleus, F:ATP binding, F:calcium ion binding, F:calmodulin binding, F:calmodulin-dependent protein kinase activity, F:protein tyrosine kinase activity, P:calcium-mediated signaling, P:MAPK cascade, P:positive regulation of transcription, DNA-templated, P:protein autophosphorylation, P:regulation of protein kinase activity, F:protein serine/threonine kinase activity, C:cytoplasm, P:positive regulation of transcription, DNA-dependent, F:protein kinase activity
UniProt3D-structure, Acetylation, Alternative splicing, ATP-binding, Calmodulin-binding, Cell projection, Complete proteome, Cytoplasm, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.620.04cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)3.780.04cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.640.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)3.240.02cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.430.0415RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.460.0000236RNA microarray19698090
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.432.36E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium