CKDdb-logoCKDdb - Molecule ID A6828

geneCCBL1, BETA-LYASE
nameGlutamine-phenylpyruvate aminotransferase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
KAT1_HUMANQ16773ENSG00000171097883Hs.495250600547

Functions and classifications

GOC:cytosol, C:nucleus, F:cysteine-S-conjugate beta-lyase activity, F:glutamine-phenylpyruvate transaminase activity, F:kynurenine-oxoglutarate transaminase activity, F:L-glutamine:pyruvate aminotransferase activity, F:L-phenylalanine-oxaloacetate transaminase activity, F:L-phenylalanine:pyruvate aminotransferase activity, F:pyridoxal phosphate binding, P:cellular amino acid biosynthetic process, P:L-kynurenine catabolic process, P:L-phenylalanine catabolic process, P:tryptophan catabolic process, F:catalytic activity, P:biosynthetic process, C:cytoplasm, F:lyase activity, F:transaminase activity, P:metabolic process
UniProt3D-structure, Alternative splicing, Aminotransferase, Complete proteome, Cytoplasm, Lyase, Pyridoxal phosphate, Reference proteome, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.460.00119RNA microarray19698090
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.810.01MALDI-TOF/TOF21544065
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.220.012MALDI-TOF/TOF21544065
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.28< 0.05RNA microarray21752957
Exp22061828Rattus norvegicus kidney Gentamicin_induced (Gentamicin-induced nephropathy)0.362.30E-05Nano RP-LC, MALDI-TOF22061828
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)8.120.006579RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium