CKDdb-logoCKDdb - Molecule ID A6825

geneAK3L1, AK3L2, AK3
nameAdenylate kinase isoenzyme 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
KAD4_HUMANP27144ENSG00000162433100507855Hs.10862103030

Functions and classifications

GOC:mitochondrial matrix, F:adenylate kinase activity, F:ATP binding, F:GTP binding, F:nucleoside diphosphate kinase activity, F:nucleoside triphosphate adenylate kinase activity, P:AMP metabolic process, P:ATP metabolic process, P:brain development, P:GTP metabolic process, P:liver development, P:nucleoside triphosphate biosynthetic process, P:response to drug, P:nucleotide phosphorylation, P:response to organic cyclic compound, P:response to organic nitrogen, C:mitochondrion
UniProt3D-structure, Acetylation, ATP-binding, Complete proteome, GTP-binding, Kinase, Mitochondrion, Nucleotide-binding, Reference proteome, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes) < 0.05MALDI-TOF-MS17609286
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.420.04cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)0.220.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.420.0135RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.349.59E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.351.50E-05RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)down MS/MS, LTQ LX linear ion trap20093355
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)3.780.016MALDI-TOF/TOF21544065
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.090.00000125RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.160.0000612RNA microarray23291264
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.30.049812581LC-MS/MS24172336
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)0.71< 0.05LC-MS/MS24497609

Compile date 08-10-2018© iMODE-CKD consortium