CKDdb-logoCKDdb - Molecule ID A6710

geneALAD
nameDelta-aminolevulinic acid dehydratase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
HEM2_HUMANP13716ENSG00000148218210Hs.1227125270, 612740

Functions and classifications

GOC:cytosol, F:lead ion binding, F:porphobilinogen synthase activity, F:zinc ion binding, P:cellular response to interleukin-4, P:heme biosynthetic process, P:protein homooligomerization, P:protoporphyrinogen IX biosynthetic process, P:small molecule metabolic process, F:metal ion binding, P:porphyrin-containing compound biosynthetic process, P:tetrapyrrole biosynthetic process
UniProt3D-structure, Allosteric enzyme, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, Heme biosynthesis, Lyase, Metal-binding, Phosphoprotein, Polymorphism, Porphyrin biosynthesis, Reference proteome, Zinc
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666bMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)4.110.05RNA microarray17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.0062RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.591.72E-05RNA microarray20019191
Exp20940332Mus musculus kidneycollecting duct cellsVasopressine_induced (Vasopressine in vitro model)1.32< 0.05LC-MS/MS20940332
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.240.000322RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.410.0107RNA microarray23291264
Exp24172336Mus musculus6kidneycortexAKI (AKI)2.940.014607994LC-MS/MS24172336
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)4.570.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium