CKDdb-logoCKDdb - Molecule ID A6552

geneAbat, Gabat
name4-aminobutyrate aminotransferase, mitochondrial
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
GABT_MOUSEP61922ENSMUSG00000057880268860Mm.259315137150, 613163

Functions and classifications

GOC:4-aminobutyrate transaminase complex, C:mitochondrial matrix, C:mitochondrion, C:neuron projection, F:(S)-3-amino-2-methylpropionate transaminase activity, F:4-aminobutyrate transaminase activity, F:protein homodimerization activity, F:pyridoxal phosphate binding, F:succinate-semialdehyde dehydrogenase binding, P:behavioral response to cocaine, P:copulation, P:gamma-aminobutyric acid metabolic process, P:locomotory behavior, P:negative regulation of blood pressure, P:neurotransmitter catabolic process, P:response to drug, P:response to ethanol, P:response to hypoxia, P:response to iron ion, P:response to nicotine, C:mitochondrion, F:4-aminobutyrate transaminase activity, F:pyridoxal phosphate binding, P:gamma-aminobutyric acid metabolic process, C:mitochondrion, F:4-aminobutyrate transaminase activity, F:pyridoxal phosphate binding, P:gamma-aminobutyric acid metabolic process, C:mitochondrion, F:4-aminobutyrate transaminase activity, F:pyridoxal phosphate binding, P:gamma-aminobutyric acid metabolic process, C:mitochondrion, F:4-aminobutyrate transaminase activity, F:pyridoxal phosphate binding, P:gamma-aminobutyric acid metabolic process
UniProtAcetylation, Alternative splicing, Aminotransferase, Complete proteome, Direct protein sequencing, Disulfide bond, Mitochondrion, Neurotransmitter degradation, Pyridoxal phosphate, Reference proteome, Transferase, Transit peptide
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.390.01cDNA microarray  19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease) 0.490cDNA microarray  19099603
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.42.26E-05RNA microarray  20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 1.412.62E-05RNA microarray  20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 0.34< 0.05RNA microarray  21752957
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity) 0.140.0000432RNA microarray  23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity) 0.340.00273RNA microarray  23291264
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI) 0.470.00113RNA microarray  24569379

Compile date 08-30-2016© iMODE-CKD consortium