CKDdb-logoCKDdb - Molecule ID A648C

geneTTR, PALB, TBPA
nameTransthyretin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
TTHY_HUMANP02766ENSG000001182717276Hs.427202105210, 115430, 145680, 176300

Functions and classifications

GOC:cytoplasm, C:extracellular region, C:extracellular space, C:protein complex, F:hormone binding, P:extracellular matrix organization, P:phototransduction, visible light, P:retinoid metabolic process, P:retinol metabolic process, P:transport, C:cytoplasm, P:transport
UniProt3D-structure, Amyloid, Amyloidosis, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Gamma-carboxyglutamic acid, Glycoprotein, Hormone, Neuropathy, Polymorphism, Reference proteome, Secreted, Signal, Thyroid hormone, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17081055Rattus norvegicus12urinewholeGlomerulonephritis (membranous nephropathy)down< 0.05MALDI 17081055
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.1195nanoLC-ESI-MS/MS 17301227
Exp17327332aHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy)0.23< 0.05LC-MS/MS 17327332
Exp17616219Rattus norvegicus10urinewholeGlomerulonephritis (Passive Heymann Nephritis)2.550.027MALDI-TOF-MSwestern blot, ELISA17616219
Exp18095357Homo sapiens38urinewholeGlomerulonephritis (IgA nephropathy)3.80.0024nano-HPLC-ESI-MS/MS 18095357
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.220.0000779RNA microarray 19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap 20093355
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS 20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS 20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS 20411046
Exp20639044bHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)4.3< 0.05LC-MS/MS 20639044
Exp21354196Mus musculus24urinewholeCyclosporine_A_induced (cyclosporine A nephrotoxicity)65.49 MS/MS 21354196
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.470.0131QSTAR Elite LC-MS/MS 22172726
Exp22498882Homo sapiens10urinewholeGlomerulonephritis (lupus nephritis)4.590.019ESI-Q-TOF MS/MS 22498882
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)1.460.02hybrid quadrupole-TOF, LC-MS/MS 22536212
Exp22891811aHomo sapiens10urinewholeureteral_obstruction (congenital bilateral hydronephrosis)0.58 +/- 0.032 < 0.05LC-MS/MS 22891811
Exp22891811bHomo sapiens10urinewholeureteral_obstruction (congenital bilateral hydronephrosis)0.58 +/- 0.040< 0.05LC-MS/MS 22891811
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)1.880.00008LC-MS/MSMRM23228063
Exp23506792bMus musculus10urinewholeDiclofenac_induced (diclofenac-induced renal injury) < 0.05MALDI-TOF MS 23506792
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)1000 1DE, MALDI 24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI 24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)1000 1DE, MALDI 24096133
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)1.41< 0.05LC-MS/MS 24497609
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.10.00393RNA microarray 24569379
Exp24761003bRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)1.52< 0.05LC-MS/MS 24761003
Exp24761003cRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)0.9< 0.05LC-MS/MS 24761003
Exp24927646aMus musculus16kidney Diabetes (diabetic nephropathy treated with Phlorizin)1.83< 0.05LC-MS/MS 24927646
Exp24927646bMus musculus16kidney Diabetes (diabetic nephropathy)2.83< 0.05LC-MS/MS 24927646

Compile date 08-10-2018© iMODE-CKD consortium