CKDdb-logoCKDdb - Molecule ID A606F

geneCASP6, MCH2
nameCaspase-6 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CASP6_HUMANP55212ENSG00000138794839Hs.654616601532

Functions and classifications

GOC:cytosol, C:nucleoplasm, F:cysteine-type endopeptidase activity, P:cellular component disassembly involved in execution phase of apoptosis, P:proteolysis, P:apoptotic process, P:acute inflammatory response to non-antigenic stimulus, P:induction of apoptosis, P:lens development in camera-type eye, P:positive regulation of neuron apoptotic process, P:positive regulation of retinal cell programmed cell death, P:response to cytokine stimulus, P:response to estradiol stimulus, P:response to gamma radiation, P:response to glucose stimulus, P:response to heat, P:response to hydrogen peroxide, P:response to iron ion, P:response to organic nitrogen, P:response to testosterone stimulus, C:nucleus, C:cytoplasm
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Hydrolase, Phosphoprotein, Polymorphism, Protease, Reference proteome, Thiol protease, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)2.350.0659RNA microarray20847290
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.12< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.62< 0.05RNA microarray21752957
Exp23505438aHomo sapiens kidneyproximal tubular cellsDiabetes (diabetic nephropathy)0.750.032cDNA microarray23505438

Compile date 08-10-2018© iMODE-CKD consortium