CKDdb-logoCKDdb - Molecule ID A6012

geneCBS
nameCystathionine B-synthase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CBS_HUMANP35520ENSG00000160200875Hs.533013236200, 613381

Functions and classifications

GOC:cytosol, C:nucleolus, F:adenyl nucleotide binding, F:cystathionine beta-synthase activity, F:heme binding, F:metal ion binding, F:modified amino acid binding, F:protein homodimerization activity, F:pyridoxal phosphate binding, P:blood vessel remodeling, P:cartilage development involved in endochondral bone morphogenesis, P:cellular nitrogen compound metabolic process, P:cellular response to hypoxia, P:cerebellum morphogenesis, P:cysteine biosynthetic process from serine, P:cysteine biosynthetic process via cystathionine, P:endochondral ossification, P:homocysteine catabolic process, P:hydrogen sulfide biosynthetic process, P:L-cysteine catabolic process, P:L-serine catabolic process, P:maternal process involved in female pregnancy, P:negative regulation of apoptotic process, P:regulation of blood vessel size, P:regulation of cGMP metabolic process, P:regulation of JUN kinase activity, P:response to folic acid, P:superoxide metabolic process, P:transsulfuration, C:cytoplasm, P:cysteine biosynthetic process, F:cysteine synthase activity, F:transferase activity
UniProt3D-structure, Allosteric enzyme, Alternative splicing, Amino-acid biosynthesis, CBS domain, Complete proteome, Cysteine biosynthesis, Cytoplasm, Disease mutation, Heme, Iron, Isopeptide bond, Lyase, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Pyridoxal phosphate, Reference proteome, Ubl conjugation, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.190.00000243RNA microarray19698090
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.120.0000181RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.170.000758RNA microarray23291264
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.44< 0.05RNA-seq23757392
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.430.00304RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium